Aminobenzoic acids and derivatives
Apexbio Technology LLC Gabexate mesylate 56974-61-9 50mg
Gabexate mesylate (CAS 56974-61-9) is a synthetic non-antigenic inhibitor targeting serine proteases including human and bovine trypsin It competitively binds the primary specificity pocket (S1) of trypsin enzymes interacting primarily through its carbonyl group at the enzyme s oxyanion binding site Reported Ki values are 3 4 nM for human trypsin and 180 nM for bovine trypsin Gabexate mesylate also inhibits nitric oxide synthases (cNOS and iNOS Ki 150 M and 5 mM respectively) suppressing LPS/IFN -induced NO production (EC50 250 M) It is employed in research related to pancreatitis coagulation disorders and inflammation
Apexbio Technology LLC Saquinavir mesylate 149845-06-7 200mg
Saquinavir mesylate is a reversible inhibitor of HIV protease a retroviral aspartic protease required for viral maturation and replication It targets the active site of HIV-1 and HIV-2 proteases preventing enzymatic cleavage of polyprotein precursors thereby suppressing formation of mature viral particles Saquinavir inhibits HIV-1 protease with a reported Ki value of approximately 0 12 nM In cultured human neuronal cells it also reduces -amyloid (A 40) levels and inhibits -secretase (BACE1) activity at 50 M concentration it reduces neuronal A production by approximately 90% Saquinavir is commonly employed in HIV/AIDS research and has potential in Alzheimer s disease models for studying the modulation of amyloid peptide synthesis pathways
AdipoGen Phomoxanthone A
Chemical. CAS 359844-69-2. Formula C38H38O16. MW 750.7. Isolated from fungus Phomopsis sp M4. Mycotoxin Antibacterial against Gram-positive bacteria. Shows antimalarial and antitubercular activity. Anticancer compound. Cytotoxic against several cancer cell lines pro-apoptotic activity. Active against plant pathogene fungi e.g. P. oryza, Phyt. infestans. Activator of murine T lymphocytes, NK cells and macrophages.
AdipoGen Anthrance A
Chemical. CAS 185318-74-5. Formula C20H8F4O5. MW 404.27. Fluorescent probe/dye with high absorbance and favorable resistance to photobleaching. Spectral Data Absorption/Emission=508/527nm.
AdipoGen Anthrance A
Chemical. CAS 185318-74-5. Formula C20H8F4O5. MW 404.27. Fluorescent probe/dye with high absorbance and favorable resistance to photobleaching. Spectral Data Absorption/Emission=508/527nm.
Ambeed 4 4 4 5 5Tetramethyl1 3 2dioxa
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridine, 2020070-33-9, 98%
Apexbio Technology LLC Safinamide Mesylate 202825-46-5 50mg
Safinamide Mesylate (CAS 202825-46-5) is the mesylate salt form of safinamide a selective and reversible inhibitor of monoamine oxidase B (MAO-B) Safinamide exhibits an IC50 of 98 nM for MAO-B inhibition leading to enhanced dopaminergic transmission by reducing dopamine degradation In addition to MAO-B inhibition safinamide modulates sodium and calcium channels (IC50 8 2 M and 31 5 M respectively) and suppresses glutamate release ( 56 4 M) contributing to its anticonvulsant properties Research applications include the study of Parkinson s disease mechanisms and the investigation of dopaminergic and glutamatergic modulation
Apexbio Technology LLC Polyphyllin A 50773-41-6 20mg
Polyphyllin A (CAS 50773-41-6) is a steroidal saponin isolated from the rhizomes of Paris yunnanensis Franch It is known to modulate multiple cellular signaling pathways including the induction of apoptosis and inhibition of proliferation in various cancer cell lines Polyphyllin A exerts its biological activity by affecting mitochondrial membrane potential promoting cytochrome c release and activating caspase cascades Due to these properties it serves as a valuable tool for investigating cell death mechanisms and evaluating potential anticancer strategies in preclinical biomedical research The compound is soluble in methanol and ethanol and should be stored sealed in a cool dry environment
Cayman Chemical NOLosartan A Other Receptor Mo
A potent AT1 receptor antagonist linked to an NO-donor; possesses similar anti-hypertensive effects to losartan, with the addition of the vasodilating effects of NO release